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Tumor Category

头颈部肿瘤

共 8 篇文章

IF 98.4RCT头颈部肿瘤2026-03

Pimicotinib versus placebo for tenosynovial giant cell tumour (MANEUVER): an international, randomised, placebo-controlled, phase 3 trial

Xu H, Niu X, Ravi V, Martin-Broto J, Razak AA, Saleh R, et al. · Lancet

结论pimicotinib显著提高TGCT患者缓解率,安全性良好,具备临床应用潜力。

PMID: 41796601DOI ↗
IF 45.3RCT头颈部肿瘤2026-03

STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma

Colman H, Lombardi G, Wong ET, Walbert T, Eoli M, Lassman AB, et al. · J Clin Oncol

结论依氟诺辛联合洛莫司汀显著延长IDH突变复发性3级星形细胞瘤患者的PFS和OS,具有良好临床应用前景。

PMID: 41325560DOI ↗
IF 45.3Other头颈部肿瘤2026-03

Pembrolizumab With or Without Lenvatinib as First-Line Therapy for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Phase III LEAP-010 Study

Licitra L, Tahara M, Harrington K, Olivera Hurtado de Mendoza M, Guo Y, Aksoy S, et al. · J Clin Oncol

结论lenvatinib联合pembrolizumab显著改善R/M HNSCC患者的ORR和PFS,但未延长OS,安全性符合预期。

PMID: 41818638DOI ↗
IF 20.1RCT头颈部肿瘤2026-01

Vebreltinib for Previously Treated Astrocytoma, <i>IDH</i>-Mutant, Grade 4, and Glioblastoma, <i>IDH</i> Wild-Type with <i>PTPRZ1-MET</i> Fusion Gene: A Multicenter, Phase III Randomized, Open-Label Trial

Bao Z, Xue Y, Liu Y, Li S, Wang L, Qu Y, et al. · Cancer Commun (Lond)

结论vebreltinib显著改善携带<i>PTPRZ1-MET</i>融合基因高等级胶质瘤患者的生存

PMID: 41821581DOI ↗
IF 16.6Other头颈部肿瘤2026-03

Intraoperative fluorescence-guided fresh frozen sectioning for margin control in head and neck cancer: phase 2 clinical trial

Nijboer TS, Keizers B, Boeve K, Roos D, de Visscher SAHJ, Halmos GB, et al. · Nat Commun

结论FG-FFS技术在头颈癌术中切缘评估中可靠且可行,有助于提高手术切缘阴性率并减少辅助治疗。

PMID: 41807438DOI ↗
IF 12.8RCT头颈部肿瘤2026-03

Patient-reported outcomes from a phase 2 PLATINUM trial of nivolumab combination therapy sparing concurrent cisplatin in nasopharyngeal carcinoma

Xu C, Lin ZQ, Wang YZ, Shen JX, Li WF, Zhou GQ, et al. · Med

结论nivolumab联合方案在鼻咽癌患者中安全有效,社会再融入可作为患者报告结局的综合指标,针对言语、吞咽及食欲减退的干预有助促进康复。

PMID: 41690301DOI ↗
IF 12.8Meta头颈部肿瘤2026-03

Incidence and spectrum of immune-related adverse events in nasopharyngeal carcinoma patients treated with immune checkpoint inhibitors

Wu KP, Luo XQ, Tan PX, Li QQ, Yang HC, Ji MC, et al. · Med

结论NPC患者接受ICI治疗时,irAEs发生率较高,需重点监测内分泌、皮肤及严重肺部和感染性并发症,平衡疗效与安全。

PMID: 41653927DOI ↗
IF 11.5Other头颈部肿瘤2026-03

CCL3+ neutrophil signature predicts response to neoadjuvant toripalimab plus chemotherapy in patients with hypopharyngeal squamous cell carcinoma: A phase II trial

Chen F, Zhou S, Ma J, Tao H, Jing P, Liu X, et al. · Clin Cancer Res

结论基线CCL3+中性粒细胞特征可预测新辅助免疫化疗疗效,为低咽癌精准免疫治疗提供有效生物标志物。

PMID: 41817286DOI ↗