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03

Tumor Category

乳腺癌

共 8 篇文章

IF 56.7Other乳腺癌2026-03

OPTIMAL: A Multinational Phase III Study of Oral Paclitaxel (DHP107) versus Intravenous Weekly Paclitaxel in HER2-Negative Recurrent or Metastatic Breast Cancer

Xu B, Jeong H, Sun T, Sohn J, Zhang Q, Kostic S, et al. · Ann Oncol

结论DHP107口服紫杉醇在HER2阴性乳腺癌中疗效非劣于静脉注射,安全性可控,提供了有效且便利的治疗选择。

PMID: 41833903DOI ↗
IF 51.1Other乳腺癌2026-03

Deep learning on histopathological images to predict breast cancer recurrence risk and chemotherapy benefit: a multicentre, model development and validation study

Shamai G, Cohen S, Binenbaum Y, Sabo E, Cretu A, Mayer C, et al. · Lancet Oncol

结论基于病理图像的AI模型可有效预测乳腺癌复发风险及化疗获益,具备推广应用潜力,有助于精准指导治疗并减少不必要化疗。

PMID: 41831466DOI ↗
IF 45.3Other乳腺癌2026-03

VIKTORIA-1 Trial of Gedatolisib Plus Fulvestrant With or Without Palbociclib in Hormone Receptor-Positive/HER2-/PIK3CA Wild-Type Advanced Breast Cancer

Hurvitz SA, Layman RM, Curigliano G, André F, Cristofanilli M, Kim SB, et al. · J Clin Oncol

结论gedatolisib联合fulvestrant,联合或不联合palbociclib,显著延长激素受体阳性/HER2阴性/PIK3CA野生型晚期乳腺癌患者的无进展生存期,具有良好临床应用前景。

PMID: 41802242DOI ↗
IF 45.3Other乳腺癌2026-03

The Pathologic Response Evaluation and Detection in Circulating Tumor-DNA Study: Ultrasensitive Circulating Tumor-DNA Assessment of Breast Cancer Minimal Residual Disease

Hunter NB, Parsons HA, Cope L, Canzoniero JV, Navarro FCP, El-Refai S, et al. · J Clin Oncol

结论新辅助治疗后ctDNA无法有效区分pCR与非pCR,但术后ctDNA检测能显著优化预后分层,指导个体化治疗调整。

PMID: 41805422DOI ↗
IF 45.3CT乳腺癌2026-03

TBCRC 048 (Olaparib Expanded) Expansion Cohorts: Phase II Study of Olaparib Monotherapy for Patients With Metastatic Breast Cancer With Germline Mutations in <i>PALB2</i> or Somatic Mutations in <i>BRCA1</i> or <i>BRCA2</i>

Tung NM, Robson ME, Li T, Nanda R, Shah PD, Khoury K, et al. · J Clin Oncol

结论奥拉帕利对携带gPALB2及sBRCA突变的转移性乳腺癌患者具有显著抗肿瘤活性,拓展了PARP抑制剂的适用人群。

PMID: 41604601DOI ↗
IF 39.0RCT乳腺癌2026-03

Camrelizumab plus CAPOX with camrelizumab based maintenance versus CAPOX alone as initial treatment for gastric or gastro-oesophageal junction adenocarcinoma: randomised phase 3 trial

Peng Z, Zhang Y, Xu H, Yang Y, Yang M, Zhang M, et al. · BMJ

结论卡瑞利珠单抗联合CAPOX及卡瑞利珠单抗维持治疗显著延长HER2阴性不可切除胃癌患者总生存期,具有良好临床应用前景。

PMID: 41819560DOI ↗
IF 23.5Other乳腺癌2026-03

Diagnostic accuracy, fairness and clinical implementation of AI for breast cancer screening: results of multicenter retrospective and prospective technical feasibility studies

Kelly CJ, Wilson M, Warren LM, Sidebottom R, Halling-Brown M, Yang L, et al. · Nat Cancer

结论Google AI系统在乳腺癌筛查中表现优异,具备替代部分人工阅片潜力,临床应用需动态校准与持续监控保障安全公平。

PMID: 41807818DOI ↗
IF 23.5Other乳腺癌2026-03

Prospective evaluation of artificial intelligence integration into breast cancer screening in multiple workflow settings: the GEMINI study

de Vries CF, Lip G, Staff RT, Dymiter JA, Tse B, Ng A, et al. · Nat Cancer

结论多种AI整合方案可提升乳腺癌筛查的临床效果和工作效率,具备根据不同医疗环境灵活应用的潜力。

PMID: 41807817DOI ↗