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02

Tumor Category

肺癌

共 8 篇文章

IF 56.7Other肺癌2026-03

MTAP Loss Is Frequent in Oncogene-Driven NSCLC and May Confer Sensitivity to Combined PRMT5 Inhibitors and Targeted Therapies

Aldea M, Lenahan S, Locquet MA, Liao L, Gasparro M, Gokhale PC, et al. · Ann Oncol

结论MTAP缺失在驱动基因突变NSCLC中常见,PRMT5抑制剂对MTAP缺失模型具有广泛活性,联合靶向治疗可能提高疗效。

PMID: 41833902DOI ↗
IF 51.1Other肺癌2026-03

Benmelstobart plus anlotinib versus pembrolizumab as first-line treatment for PD-L1-positive, advanced non-small-cell lung cancer (CAMPASS): a blinded, randomised, controlled, phase 3 trial

Zhong H, Wang J, Yang R, Luo Y, Zuo W, Zhang W, et al. · Lancet Oncol

结论benmelstobart联合anlotinib显著延长PD-L1阳性晚期NSCLC患者的无进展生存期,具有潜在临床应用价值。

PMID: 41825453DOI ↗
IF 45.3RCT肺癌2026-03

Chemoradiation ± Atezolizumab in Limited-Stage Small Cell Lung Cancer: Results of NRG Oncology/Alliance LU005

Higgins KA, Hu C, Ross HJ, Jabbour SK, Kozono DE, Owonikoko TK, et al. · J Clin Oncol

结论同步及辅助阿特珠单抗联合化疗放疗未显著改善有限期小细胞肺癌患者的生存预后。

PMID: 41529214DOI ↗
IF 20.4Other肺癌2026-03

The International Association for the Study of Lung Cancer Pleural Mesothelioma Staging Project: Impact of Common Molecular Alterations and PD-L1 Expression on Overall Survival in a Select Cohort from the IASLC 9<sup>th</sup> Edition Staging Database

Yang SR, Tjota MY, Goren E, Giroux DJ, Galateau-Salle F, Husain AN, et al. · J Thorac Oncol

结论CDKN2A、NF2及TP53突变提示胸膜间皮瘤预后较差,BAP1突变预后较好,分子标志物可为临床分期提供补充预后信息。

PMID: 41833817DOI ↗
IF 16.6Other肺癌2026-03

Pan-tumor activity of olomorasib, a next-generation KRAS G12C inhibitor in KRAS G12C-mutant advanced solid tumors: a first-in-human study

Murciano-Goroff YR, Hollebecque A, Heist RS, Cassier PA, Han JY, Kim SY, et al. · Nat Commun

结论olomorasib安全耐受,显示广谱抗KRAS G12C突变肿瘤活性,具备进一步联合治疗研究价值。

PMID: 41820335DOI ↗
IF 12.8Other肺癌2026-03

When EGFR meets MET: Dual blockade as the next post-TKI standard?

Arter ZL, Soo RA · Med

结论EGFR和MET双重抑制显著改善EGFR-TKI失败后NSCLC患者的无进展生存期,具备成为新标准治疗潜力。

PMID: 41831430DOI ↗
IF 11.5Other肺癌2026-03

Ionizing radiation enhances prognostically significant cellular immunity programs in the brain metastasis microenvironment

Fukumura K, Jiang P, Yeboa DN, Singareeka Raghavendra A, Gubbiotti MA, Andersen CR, et al. · Clin Cancer Res

结论脑转移瘤中高TCR多样性预示良好预后,放射治疗可增强免疫反应,提示放射诱导免疫调节具有潜在治疗价值。

PMID: 41817317DOI ↗
IF 11.5Other肺癌2026-03

Patient-Reported Outcomes in FLAURA2: Osimertinib with or without Chemotherapy in Patients with Previously Untreated EGFR-Mutated Advanced Non-Small Cell Lung Cancer

Gray JE, Laktionov K, Kim SW, Kato T, Wang J, Han Z, et al. · Clin Cancer Res

结论奥希替尼联合化疗作为EGFR突变晚期NSCLC一线治疗,虽提高PFS,但对患者生活质量影响轻微,耐受性良好,具临床应用价值。

PMID: 41801128DOI ↗