MTAP Loss Is Frequent in Oncogene-Driven NSCLC and May Confer Sensitivity to Combined PRMT5 Inhibitors and Targeted Therapies
Aldea M, Lenahan S, Locquet MA, Liao L, Gasparro M, Gokhale PC, et al. · Ann Oncol
结论MTAP缺失在驱动基因突变NSCLC中常见,PRMT5抑制剂对MTAP缺失模型具有广泛活性,联合靶向治疗可能提高疗效。